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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
(Cyclohexanecarbonyl)-L-leucine is a cyclohexanecarbonyl-protected derivative of the amino acid L-leucine supplied as a research reagent. It is provided as a white to off-white solid with defined purity and storage recommendations for laboratory use.
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
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Dimethyl trisulfide (CAS 3658-80-8) is a small-molecule organosulfur compound investigated for its ability to modulate cellular signaling pathways and enzyme activities Studies indicate that it can inhibit specific intracellular signaling cascades resulting in altered regulation of cellular biological functions Due to its bioactivity dimethyl trisulfide serves as a valuable tool for elucidating disease mechanisms involving the affected pathways and for evaluating potential therapeutic strategies in biomedical research
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TUG-770 (CAS 1402601-82-4) is a potent agonist of the free fatty acid receptor 1 (FFA1/GPR40) a G protein-coupled receptor implicated in the enhancement of glucose-stimulated insulin secretion by pancreatic -cells TUG-770 demonstrates high affinity for FFA1 with an EC50 of 6 nM and over 150-fold selectivity compared to FFA4 as well as high selectivity over other receptors and transporters In INS-1E rat -cell lines TUG-770 promotes insulin secretion in the presence of elevated glucose Pharmacokinetic studies in mice indicate favorable oral absorption and bioavailability with dose-dependent reductions in blood glucose during glucose tolerance tests TUG-770 is a valuable tool for investigating FFA1-mediated pathways and glucose homeostasis in metabolic research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More